New TB drug cocktail

Defusing the new drug-resistant TB time bomb.

New TB control recommendations call for four-drug regime and HIV testing of TB patients.

Hospital May Lose Federal Funding for Discriminating Against HIVPositive Healthcare Worker A New York state case marks the first time that the Department of Health and Human Services (HHS) has ordered termination of a hospital’s federal funds, some 40% of this hospital’s revenue, for a civil rights violation since the implementation of Medicare’s hospital prospective payment system. This hospit...

Drug Cocktail Optimization in Chemotherapy of Cancer

BACKGROUND In general, drug metabolism has to be considered to avoid adverse effects and ineffective therapy. In particular, chemotherapeutic drug cocktails strain drug metabolizing enzymes especially the cytochrome P450 family (CYP). Furthermore, a number of important chemotherapeutic drugs such as cyclophosphamide, ifosfamide, tamoxifen or procarbazine are administered as prodrugs and have to...

Management of Drug-Resistant TB

MDR-TB and XDR-TB: drug resistance and treatment outcomes.

The subject is quite topical, as TB programmes and clinicians are searching for solutions to treat MDR/XDR-TB most effectively. Recently published studies and a systematic review have shown that XDR-TB is associated with higher probability of failure and death, and lower probability of treatment success than MDR-TB [2–7]. The XDR-TB-defining drugs have been studied to evaluate their role in det...